ABSTRACT
ABSTRACT Background: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created. Objective: The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients and thus select which patients would require a chest imaging study. Materials and Methods: We conducted a cross-sectional study in a cohort of individuals with suspected COVID-19 evaluated in a public academic healthcare center in Buenos Aires city. All adult patients with positive RT-PCR assay for SARS-COV2 between April 24 and May 19 of 2020 were included in the study. Pneumonia was defined as the presence of compatible signs and symptoms with imaging confirmation. Univariate and multivariate logistic regression was performed. A risk indicator score was developed. Results: One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age ≥ 40 years, cough, absence of sore throat, and respiratory rate ≥ 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate ≥ 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value of 2 showed a sensitivity of 95.7% and a specificity of 43.24%. Conclusion: This sensible score may improve the risk stratification of COVID-19 patients in the pre-hospital setting. (REV INVEST CLIN. 2021;73(1):52-8)
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Pneumonia, Viral/diagnosis , Fever/diagnosis , COVID-19/complications , Intensive Care Units , Argentina , Pneumonia, Viral/etiology , Severity of Illness Index , Risk , Cross-Sectional Studies , Prospective Studies , Cohort Studies , Sensitivity and Specificity , Reverse Transcriptase Polymerase Chain Reaction , Fever/virology , COVID-19/diagnosisABSTRACT
Introduction: Little is known about incidence, anatomical and clinical characteristics and results of endovascular treatment of the internal carotid artery (ICA) aneurysms. This type of the aneurysms can be approached by surgical with low morbidity and mortality. Clinical presentation: a 48-year-old woman submitted an endovascular embolization treatment in 2005, and in 2009 presents a new bleeding. The angiography shows that the same aneurysm was ruptured and a surgical repair was proposed. The surgical management shows detachable coils in the brain parenchyma. Conclusion: Some endovascular surgeons preferred the less invasive procedure (endovascular treatment) for intracranial aneurysms, but the surgical repair still remains the best choice for definitive treatment for intracranial aneurysms.
Subject(s)
Humans , Female , Middle Aged , Intracranial Aneurysm/surgery , Intracranial Aneurysm/diagnosis , Intracranial Aneurysm/mortality , Carotid Artery, Internal , Carotid Artery, Internal, Dissection/surgery , Carotid Artery, Internal, Dissection/diagnosisABSTRACT
Los tumores germinales extragonadales representan entre el 1 y 2.5% de los tumores de células germinales (TCG), siendo el mediastino la segunda localización en frecuencia luego de las gónadas. Se presenta el caso de un paciente masculino de 29 años de edad que consulta por tos irritativa de cinco meses de evolución. Se realizaron radiografía, tomografía computada (TC) y resonancia magnética (RM) de tórax y ecografía testicular. Los hallazgos por imágenes, sumados a la presencia de marcadores tumorales elevados (alfa-fetoproteína y gonadotrofina coriónica humana), confirmaron el diagnóstico de TCG extragonadal, avalado posteriormente por la cirugía y la anatomía patológica.
The prevalence of extragonadal germ cell tumors is only 1- 2.5% of all germ cell tumors. The mediastinum is the second most common site affected. We present the case of a 29 years old male pacient, with a persistent cough dating back to five months. We performed chest X-R, thorax CT and MRI and testicular US. The findings of this images besides the presence of elevated levels of alpha-fetoprotein and beta-human gonadotropin confirm the diagnosis of extragonadal germ cell tumor.
ABSTRACT
Propósito. Evaluar la distribución anatómica de las opacidades en vidrio esmerilado y las alteraciones estructurales parenquimatosas asociadas, correlacionándolas con las diferentes etiologías. Material y método. Se estudiaron retrospectivamente 38 pacientes, 22 hombres y 16 mujeres, entre 20 y 88 años, (promedio 54,6), mediante TCAR, haciendo cortes de 2 mm cada 10 mm de incremento de camilla, con inyección de contraste iodado en 11 pacientes. El diagnóstico definitivo se efectuó por estudio del esputo, lavado bronquioloalveolar, biopsia transbronquial y a cielo abierto. Resultados. El análisis obtenido se basó en la distribución anatómica de las opacidades en vidrio esmerilado y en las alteraciones estructurales parenquimatosas pulmonares. Distribución centrolobular: se relacionó con la afectación temparna del espacio aéreo con infección (21 casos), sangre (4 casos), en neumonitis por hipersensibilidad (1 caso) y en neumonitis intersticial descamativa (1 caso). Distribución panlobular: se observó en proteinosis alveolar (1 caso), toxicidad por drogas (1 caso), sarcoidosis (1 caso) y neumonía por pneumocystis carinii (1 caso), silicoproteinosis (1 caso). Distribución periférica: fibrosis pulmonar (1 caso) y bronquiolitis obliterante (1 caso). Las alteraciones estructurales asociadas fueron: bronquiectasis (10 casos), quistes (3 casos), bandas lineales densas subpleurales, engrosamiento de septos intersticiales (4 casos), engrosamiento peribroncovascular o nodulillar con microquistes concomitantes (1 caso) y enfisema (18 casos). Conclusión. La tomografía computada de alta resolución ha sido una herramienta diagnóstica útil en la investigación del patrón en vidrio esmerilado, así como en las alteraciones estructurales parenquimatosas concomitantes, habiendo logrado aproximarnos al diagnóstico etiológico en la mayoría de los casos, dentro del contexto clínico y orientar al médico de cabecera en la conducta terapéutica en los restantes
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Lung , Pulmonary Alveolar Proteinosis , Pulmonary Fibrosis , Sarcoidosis, Pulmonary , Tuberculosis, Pulmonary , Adenocarcinoma, Bronchiolo-Alveolar , Bronchiolitis Obliterans , Hemorrhage , Lung Diseases, Interstitial , Lung , Lung/pathology , Pulmonary Edema , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
T-cell rich B-cell lymphomas (TCRBCL) are characterized as non-Hodgkin lymphomas with a minor population of malignant B-cells scattered among predominant, reactive T-lymphocytes. This entity can easily be confused with lymphocyte-predominant Hodgkin disease (HD-LP), resulting in inappropriate therapy and a poor outcome. Because of their similarity, the pathology of patients treated for HD-LP with an inadequate or short-lived response to therapy should always be reviewed by an expert hematopathologist. We describe the first reported patient in Puerto Rico with TCRBCL, originally diagnosed and treated as HD-LP. Although the patient received partial, substandard therapy for TCRBCL, an excellent prolonged complete response ensued, thus, giving further credence to the fact that malignant lymphomas and TCRBCL in particular, are a protean group of disorders which should be precisely and accurately classified before the proper therapeutic strategies can be outlined